eIF4E和MMP9在子宮內(nèi)膜癌中的表達及臨床意義.pdf

1、分類號：R737.33密級：不保密UDCUDC：610學(xué)校代碼：11065碩士學(xué)位論文eIF4E和MMP9在子宮內(nèi)膜癌中的表達及在子宮內(nèi)膜癌中的表達及臨床臨床意義意義解秀楊指導(dǎo)教師王蓁教授學(xué)科專業(yè)名稱婦產(chǎn)科學(xué)論文提交日期2016年4月12日論文答辯日期2016年5月27日答辯委員會主席楊興升教授指導(dǎo)指導(dǎo)教師：王蓁教師：王蓁教授教授關(guān)鍵詞：子宮內(nèi)膜癌；真核翻譯起始因子關(guān)鍵詞：子宮內(nèi)膜癌；真核翻譯起始因子4E4E；基質(zhì)金屬蛋白酶；基質(zhì)金屬蛋

2、白酶9；免疫組化；免疫組化ExpressionSignificanceofeIF4EMMP9inEndometrialCarcinomaABSTRACTObjectiveToinvestigatetheacteristicexpressionsofeukaryotictranslationinitiationfact4E(eIF4E)matrixmetalloproteinase9(MMP9)inendometrialcarcinoma

3、studythecrelationbetweentheexpressiontheclinicalsignificanceofendometrialcarcinoma.MethodseIF4EMMP9weredetectedbyimmunohistochemicalmethodin16casesofnmalendometrialtissues10casesofendometrialhyperplasia42casesofendometri

4、alcarcinomatoanalyzetheirexpressionacteristics.Thecrelationbetweentheexpressiontheclinicalpathologicalfeaturesofendometrialcarcinomawasalsoanalyzed.Results1.ThepositiveexpressionrateofeIF4EMMP9increasedstatisticallyinnma

5、lendometrialtissueshyperplasiaendometriumendometrialcarcinomathedifferencesbetweenthethreegroupswerestatisticallysignificant(P＜0.05).therewerestatisticallysignificantdifferencesbetweennmalendometrialtissuesendometrialcar

6、cinoma(P＜0.0167).2.TheexpressionlevelsofeIF4EMMP9werecloselycrelatedwiththeFIGOstagehistologicalgradelymphmetastasis(P＜0.05).3.TheexpressionofeIF4EwaspositivelycrelatedwiththeexpressionofMMP9inendometrialcarcinoma(r＝0.71