晚期非小細(xì)胞肺癌圍化療期中藥參與治療回顧性臨床研究.pdf

1、北京中醫(yī)藥大學(xué)博士學(xué)位論文晚期非小細(xì)胞肺癌圍化療期中藥參與治療回顧性臨床研究姓名：侯麗申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：中西醫(yī)結(jié)合臨床指導(dǎo)教師：陳信義200405012晚期非小細(xì)胞肺癌固化療期中藥參與治療回顧性臨床研究ABSTRACTPrimarybronchiallungcancea“isoneofthemostcornnlonmalignanttBnlors／ts5yealSurvivalrateislessthan15％Amongwhich

2、80％arenon，srm／1celllungcancerfNSCLC)75％ofpatientsareintheadvancedstage(stageIIIBorstageIV)whendiagnosedmissingt11eoppommityofaradicaloperation11把multimodalitytherapyiSrecommendedatpresent；itsaimistoimprovethequalityoflif

3、eandextendsurvivaltimeLiteratureshowsthattheinterventionofChinesemedicineinthepefichemotherapeutiestageofadvancedNSCLCcanminimizethetoxicandsideeffectsofchemotherapyincreasechemotherapycompleteratesandremissionratesrelie

4、vesymptomsandimprovequalityoflifeHoweverduetOthelackofpolycentricbigsamplingandstandardizedclinicaldatatherealestillnoenoughevidencetoprovetheadvantageofTCMintervenfionandinstmctstandardizedtreatmentThisstudyinitiallyatt

5、emptedtoconductaclinicalretrospectivecomparativestudyofthe211advancedNSCLCcasesadmittedin7firstgradefirstclassBeijinghospitalsfromJanuary1998toDecember2003，106casesofwhichbelongtothewesternmedicine(W啪groupand105casesbclo

6、t瑪totheim孵atedTCMandwesternmedicine(integratedTCMandWM)groupRemitsshow：O)compalisonofprelrealmentbasalinformationshowthatthepatientsDftheintegratedTCMandWlVlgrouparerelativelyolderamongwhich6898％areseniorpatients；thescor

7、esofKPSaresignificantlylowerthanthatoftheWlVIgroup；alsomorepatientshavecomplicationssuchaspainandanemi扎②Evaluationofimmediateeffectsshowthatbothgroupsdonothavecompleteresponse(㈣cases；船fbrthepartialresponse口R)Cases，therea

8、re39fortheWMgroup(3714％)and23矗)rtheintegratedTCMandWMgr(xtp(2l，9㈣；forstablediseasecasesthereare42fortheWMgroupand66fortheintegratedTCMandWMgroup40／oand6286％respectively：forprogressivediseaseca鼢，thereare24fbr也eWMgroupand1

9、6for齜integratedTCMandWMgroup2286％and1524％respectively111eCRPRofbothgroupsshowsignificantstatisticaldifference(PO05)，whereintheW／VlgroupprovestobebetterthantheintegratedTCMandW／Vlgroup；theCRPRSDofbothgroupsshow110signific

10、antstatisticaldifference(em05)；whenevaluatingthePDcasesofbothgroups，thepercentageoftheWMgroupishigherthanthatoftheintegratedTCMandWMgroup‰qualityoflife(QOL)evaluationprovesthatthepost拄eatmentintegratedTCMandWMgrouphasasi

11、gnificantincreaseinthescoresofKPS，thepercentagesofincreaseintheStoresOfKPSaret604％and6000／o，WIVigroupandintegratedTCMandW／vlgrouprespectively；thepercentagesofconstancyale5415％and37，1乃矗WMgroupandintegratedTCMandWMgroup，re

12、spectively；thepercentagesofdecreaseare1981％and28覦WMgroupandintegratedTCMandWMgrouprespectivelyThescoresofKPSofbothgroupsshowverysignificantstatisticaldifference㈣0001)provingthatTCMinterventionintreatmentcanimprovethequal