超臨界流體制備植物甾醇超細(xì)微粒的研究.pdf

1、上海交通大學(xué)碩士學(xué)位論文超臨界流體制備植物甾醇超細(xì)微粒的研究姓名：陳敏申請學(xué)位級別：碩士專業(yè)：應(yīng)用化學(xué)指導(dǎo)教師：趙亞平20030101上海交通大學(xué)碩士論文4TheStudyonMicronizationofPhytosterolbySupercriticalFluidsAbstractSupercriticalprocessesarenewtechnologytoprepareparedwithtraditionalmicronizat

2、ionprocessessupercriticalprocesseshavesomepotentaladvantagesfexampletheoperatingconditionismildtheparticlesaresmallerwithanarrowcrystalsizedistributationthetechnologyiswellappliedwithindustrialarea.Nowthesupercriticalpro

3、cessesconsistof“RapidExpansionfromSupercriticalSolutions(RESS)”“SupercriticalAntisolvent(SAS)”.Thephytosterolispolysolubleinaqueoussolutionsitreducebioavailability.Apromisingmethodtoimprovebioavailabilityisthemicronizati

4、onofphytosterol.Thepaperhavesucceededinpreparingthemicroparticleswith1umbythesupercriticalprocessesdesignedbymyselfTheapparatusdesignedbythepapernotonlyisperfmedasRESSbutalsoasSAS.Theadvantagesoftheapparatusisthatitadapt

5、todifferentprocessarrangementsitsnozzleiseasytobefixedtakendown.InRESSexperimentphytosterolparticleswiththesizeof1umnarrowsizedistributionareproduced.Theinfluenceofsomepreexpansioncoditionspostexpansionconditionsisinvest

6、igeted.Smallerparticleswiththesizeof100nmareacquiredbycontrolingthegrowthofcrystal.In“ContinuousOperation”experimenttheparitcleswiththesizefrom1umto50umhavebeenproduced.ThenozzlediameterhasmeinfluenceonparticlesizethanTe

7、Pe.Smallerdiameterwillbeabletoprodecesmallerparticles.In“LiquidBatchOperation”experimenttheparitcleswiththesizefrom1umto20umhavebeenproduced.Amongtheconditionalpramaterstherateofimprovingpressureismostimptant.Improvingth