喹唑啉酮與噻酚并嘧啶酮衍生物的合成與殺菌活性.pdf

1、華中師范大學(xué)碩士學(xué)位論文喹唑啉酮與噻酚并嘧啶酮衍生物的合成與殺菌活性姓名：楊尚君申請(qǐng)學(xué)位級(jí)別：碩士專(zhuān)業(yè)：有機(jī)化學(xué)指導(dǎo)教師：丁明武2003.5.1AbstractOuinazolinoneshavebeenfoundtoshowfungicidal，herbicidal，pestcidalandmedicinalactivities，andhavetheappliedforegroundextensivelyInthispaperwest

2、udiedthesynthesisofnovelquinazolinonesbyutilizingazaWittigreactionthathastheadvantageofeasilyaccessiblestartingmaterial，mildconditionandgoodyieldsThespectralproperties，biologicalactivitiesandtheconditionforcyelizationofq

3、uinazolinoneswerealsesearchedandsomeofthemwerefoundtoshowgoodfungicidalactivitiesSixtyfiveunreportedquinazolinonesinthreeseriesWelesynthesizedItmaybesummarizedasfollows：1Thecyclizationofcarbodiimide2withphenolsinpresence

4、ofsolidpotassiumcarbonatewasstudiedfurtherTheresultsshowthatitisagoodmethodforpreparingof2一phenoxy(thio)0H)quinzolin4ones4atroomtemperature2Thecyelizationofearbodiimide2withalcoholsinpresenceofsodiumalkoxidewasstudiedfir

5、stlyTheresultsshowthatitisagoodmethodforpreparingof2alkyloxy3Hquinzolin4ones15atnormaltemperature3Attemptousemanywaystosynthesizeiminophosphorane8resultedinabettermethodB，whichhasmanymeritssuch∞shorttime，lessstep，high—yi

6、eld，andtobeeasily—saperatedTheseprovideanimportantwaytosynthesisthieno[2，3d】Pyrimidine42substitutedthieno[2，3一d]Pyrimdine11werefirstlysynthesizedfromazaWittigreactioninsverymildcondition5Thebiologicalactivitiesofpartialq

7、uinzolinoneswerestudiedTheresultsshowedthattheyexhibitedfungicidalactivitiesEspecially2alkoxy3H—quinazolin4ones15Mostofthemexhibitedmorethan80％(gradeB、inhibitionofpartialfungiin50mg／L6Thebiologicalactivitiesofpartialthie

8、no[2，3一d]Pyrimidine11werestudiedTheresultsshowedthattheyexhibitedfungicidalactivitiesMostofthemexhibitedmorethan80％(gradeB、inhibitionofpartialfungiofbeetspecklkeywords：Quinazolinones，azaWittigmacfion，carbodiimide，thieno[