結(jié)構(gòu)可控丙烯酸琥珀酰亞胺酯均聚物-嵌段共聚物及其糖高分子的制備與表征.pdf

1、中國(guó)科學(xué)技術(shù)大學(xué)碩士學(xué)位論文結(jié)構(gòu)可控丙烯酸琥珀酰亞胺酯均聚物嵌段共聚物及其糖高分子的制備與表征姓名：胡志成申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：高分子化學(xué)與物理指導(dǎo)教師：劉業(yè)20040601ABSTRACTGlycopolymersareimportantpromisingmaterialsformanyfieldssuchastargeteddrugdeliveryandtissueengineeringduetotheircapabilityto

2、recognizingbiologicalmoleculesspecificallyHoweverglycopolymerswithwel!‘controlledstructures，ie，withnarrowmolecularweightdistributionsanddesignedglycoconjugatedegrees，areaprerequisitetofullyrealizingtheirpropertiesandappl

3、icationsNevertheless，thestructuresofglycopolymersreportedcurrentlystillcouldn’tbewelIcontrolledHere，firstlypreactivatedpolyacrylateswithwell—controlledsmlctureswerepreparedbyATRP，andtheiramphiphiliccopolymerswithpoly(L—l

4、actide)wereobtainedbyusingmacrointiatorspreparedbyATRPforthering—openingpolymerizationofL—lactideThennanoparticleswerefabricatedthroughtheselfassemblyoftheamphiphiliccopolymersobtainedinselectivesolventsFurtherhonaoglyco

5、polymerswithnarrowmolecularweightdistributionsanddesignedglycoconjugatedegreeswerepreparedbythereactionofamino—oligosaccharidewiththepreactivedpolymersInmoredetails，(1)ATRPofN—hydroxysuccinimide(NAS)wassuccessfullyperfor

6、medat80oCinitiatedbyHEBriB／CuBr／bpyGPCresultsreflectedthatthemolecularweightpolydispersityindexesofPNASobtainedrangedfrom117to129ThemolecularweightsofPNAScouldbecontrolledhythefeedratiosofmonomertOinitiatorFurtbermore，we

7、ll—definedglycoconjugatepolyacrylamides，i～ewithnarrowmolecularweightdistributionsanddesignedglycoconjugatedegrees，werepreparedbysubstitutingN—oxysuccinimideunitswithgalactosamineasamodelofoligosaccharidefollowedbyethanol

8、amineThegalactosamineconjugatedegreesweredeterminedby1H—NMRandthetotalsubstitutionsofN—oxysuccinimideswereverifiedby’HNMRandFTIR(2)Blockeopolymer，PNASb—PLLA，waspreparedbyringopeningpolymerization限OP)ofLLAinbulkat170。Cfor

9、6hbyusingHO—PNASpreparedbyATRPasmacroinitiatorandSn(Oct)2ascatalystThemolecularweightsofPNAS—bPLLAcouldbecontrolledbythefeedratiosofLLAtoHO—PNASandtheirmolecularweightdistributionswerenarrow(Mw／Mn=1121371asreflectedbyGPC