“gg-up”能量飲料亞慢性毒性試驗(yàn)實(shí)驗(yàn)報(bào)告

1、“Gup”能量飲料的能量飲料的90天喂養(yǎng)實(shí)驗(yàn)研究天喂養(yǎng)實(shí)驗(yàn)研究劉慧智鄒志飛許崇輝程樹(shù)軍陳永紅（廣東出入境檢驗(yàn)檢疫局檢驗(yàn)檢疫技術(shù)中心，廣州）【摘要摘要】目的目的評(píng)價(jià)“Gup”能量飲料的飲用安全性。方法方法采用SPF級(jí)NIH小鼠對(duì)所送樣品“Gup”能量飲料進(jìn)行了為期90天的喂養(yǎng)試驗(yàn)[1]。按體重隨機(jī)分為高劑量組、中劑量組、低劑量組和對(duì)照組，每組20只，雌雄各半。結(jié)果結(jié)果在小鼠90天喂養(yǎng)試驗(yàn)中，四組小鼠生長(zhǎng)發(fā)育正常，生理性活動(dòng)正常，未見(jiàn)中毒癥

2、狀；高劑量組小鼠血糖含量明顯高于對(duì)照組（p0.01），中劑量組血清總膽固醇及甘油三酯含量皆明顯低于對(duì)照組（p0.01）；低劑量組小鼠自主活動(dòng)次數(shù)明顯高于對(duì)照組（p0.01）。結(jié)論結(jié)論未發(fā)現(xiàn)“Gup”能量飲料對(duì)實(shí)驗(yàn)動(dòng)物造成損害，該樣品對(duì)實(shí)驗(yàn)動(dòng)物有一定的抗疲勞的作用?！娟P(guān)鍵詞關(guān)鍵詞】“Gup”能量飲料喂養(yǎng)試驗(yàn)“Gup“energydrink90daysfeedingtestLIUHuizhiZHOUZhifeiCHENGShujunXUCh

3、onghuiCENGYonghong(GuangdongEntryexitInspectionQuarantineTechnologyCenterGuangzhou510623China)【Abstract】ObjectiveEvaluationof“Gup“energydrinksafetyfdrinking.Methods20SPFNIHmice(10females10males)wereromlydividedintofourgr

4、oupsbyweighttothesample“Gup“energydrinkfa90daysfeedingtest[1].Setahighdosegroupmediumdosegrouplowdosegroupnegativecontrolgroup.ResultDuring90daysfeedingtestnoobvioustoxicsignsdeathwerefoundnoobviouschangewerefoundingross

5、necropsyfourgroupsofmicewerenmalgrowthdevelopmentphysiologicalactivitywasnmal.GLUvalueofhighdosegroupwasobviouslymethannegativenegativecontrolgroup(p0.01).Cholesteroltriglycerideofmediumdosegroupweresignificantlylessthan

6、negativecontrolgroup(p0.01).Autonomicactivityoflowdosegroupweresignificantlymethannegativenegativecontrolgroup(p0.01).ConclusionsDuring90daysfeedingtestthesamplewerefoundtheantifatiguefunctionfexperimentalanimals.【Keywds

7、】“Gup“energydrinkfeedingtest2.12.1一般情況一般情況在90天喂養(yǎng)試驗(yàn)中，四組小鼠生長(zhǎng)發(fā)育正常，體重增長(zhǎng)趨勢(shì)合理，表1；對(duì)照組雌性小鼠毛色較其他三組雌性小鼠稍差，四組雄性小鼠皆有好斗現(xiàn)象，未見(jiàn)小鼠有中毒癥狀。表1“Gup”能量飲料對(duì)小鼠體重增長(zhǎng)趨勢(shì)的影響能量飲料對(duì)小鼠體重增長(zhǎng)趨勢(shì)的影響時(shí)間高劑量組中劑量組低劑量組對(duì)照組實(shí)驗(yàn)前16.411.84(20)16.721.43(20)14.861.75(20)16.

8、251.44(20)第7天22.501.94(20)23.963.14(20)23.642.13(20)23.502.15(20)第14天26.723.07(20)27.404.46(20)27.582.88(20)26.993.02(20)第21天27.583.19(20)28.095.08(20)26.402.72(20)27.303.17(20)第28天29.963.38(20)29.055.36(20)29.023.45(20)

9、29.193.82(20)第35天31.113.83(20)30.214.74(20)30.913.74(20)30.204.00(20)第42天32.294.73(19)31.765.49(20)35.216.41(20)34.374.94(20)第49天33.484.40(19)32.575.53(20)35.827.25(20)35.354.75(20)第56天34.334.46(19)33.896.18(20)38.146.58

10、(20)34.476.68(20)第63天34.935.04(19)34.115.71(19)37.717.14(20)34.796.50(20)第70天34.725.04(19)33.235.52(19)36.056.02(20)33.105.96(20)第77天36.824.92(19)35.545.55(19)39.476.58(20)35.676.90(19)2.22.2對(duì)小鼠血象的影響對(duì)小鼠血象的影響未發(fā)現(xiàn)四組小鼠白細(xì)胞數(shù)、紅

11、細(xì)胞數(shù)、血紅蛋白含量及血小板數(shù)的明顯不同，表2。表2“Gup”能量飲料對(duì)小鼠血象的影響能量飲料對(duì)小鼠血象的影響高劑量組中劑量組低劑量組對(duì)照組WBC(109L)13.93.3(17)15.23.3(17)14.63.7(20)15.13.5(17)RBC(1012L)8.770.80(17)8.950.73(19)8.730.69(20)8.721.10(20)HGB(gL)15213(17)15414(19)14910(20)14918