有機胂類藥物與溶解性有機質(zhì)(DOM)相互作用機制研究.pdf

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3、cid(HA)一akindoftypicaldissolvedorganicmatter(DOM)andorganicarsenic，suchasroxarsone(ROX)，parsenilicacid(p—ASA)andoarsenilicacid(o—ASA)wereresearchedThemethodsofthreedimensionalfluorescencespectrum，synchronous—scalafluores

4、cencespectra，transientfluorescencesDectnunandfouriertransforminfraredspectroscopywereusedtoidentifytheinteractionbetweenHAandorganicarsenicFluorescencespectroscopeandfluorescencequenchingtitrationtechniquewereusedtoinves

5、tigatetheeffectsofHAconcentration，pH，andtemperatureonthebondingstrengthbetweenHAandorganicarsenicHAFe。organicarsetlicwaSstudiedtoclarifythefunctionofFeThemainconclusionsareasfollows：1HAcouldbequenchedbyROX，pASA，o—ASAThee

6、quilibriumbetweenthemcouldbeachievedwithin05hoursFourfluorescencepeaksofHAwereE劃Em：300mn／480nm，370nm／480nm，420nm／500um，460nm／520nmrespectlyForROX，theextentofdecreasesinfluorescenceintensitiesofdifferentpeakswasdifferenta

7、ndfolioWedanorderofCBADForpASAando—ASA，itwasAB2C2D2Transient—fluorescencespectrumanalysesandlinermodelsimulationsrevealedthatsinglestaticquenchingwasthemainmechanismbetweenROX(p—ASA，o‘ASA)andthefunctionalgroupsoffluoresc

8、encepeakA，B，DinHA，andcombineddynamicandstaticquenchingwerethemainmechanismbetweenROXandthefunctionalgroupsofpeakCinHA3FouriertransforminfraredspectroscopyanalysesindicatedaninteractionbetweengroupsofarsenicacidinROX(p—AS

9、A，oASA)andnegativeionofcarboxylicacidinHAInHA—FePOX，F(xiàn)e3playedaroleofbridgeconnection4ComparedwithHA—ROXandoASAHA，theincreasingofHAconcentrationcouldinhibitapparentlytheinteractionbetweenHAandpASAItmeansedthattheequilibri

10、umcouldberebuildedfordifferentconcentrationofHAinpASA—HATheco舢monlogarithmvalueofassociationconstants(19目werefarlargerthanthebimolecularquenchingconstantof025pHcouldchangetheformationofROX(pASA，o—ASA，F(xiàn)e”)andconformationo