2446.新型c2軸手性和手性吡咯烷酰胺催化劑的設計合成及不對稱催化反應中的應用

1、學校代碼：10663學號：4201410000391貴州師范大學碩士學位論文新型C2軸手性和手性吡咯烷酰胺催化劑的設計合成及不對稱催化反應中的應用NovelC2axisChiralChiralPyrroleAeCatalystswereDesignedSynthesizedofApplicationsinAsymmetricCatalyticReactions專業(yè)名稱：分析化學專業(yè)代碼：070302研究方向：有機合成申請人姓名：黃克俊導

2、師姓名：陳治明（教授）二〇一七年五月二十日ⅡAbstractganocatalysishasbecomeoneofthemostactiveattractivebranchinasymmetriccatalysissincethebeginningofthiscentury.Particylarythenearlylasttenyearshaswitnessdanenousgrowthconcerningnewcatalystdesig

3、nnewrectiondevelopmentnovelcatalyticconcepts.InthiscontextasymmetricenaminecatalysisHbondingcatalysisaretwoofimptantganocatalyticstrategiesthathaneasubstantialimpactonthisarea.Inspiredbythesefundermentalcatalyticstategie

4、swedesignedavaitetyofmultifunctionalchiralganocatalysts.TherefethehighercatalyticactivityofchiralpyrrolidineaeC2axialchiralBINOLaeganocatalystsweredesignedsynthesizedfmcommerciallyavailableLprolinewereusedintwodifferenta

5、symmetriccatalyticreactionhaveachievedgoodresults.1.TheasymmetricMichaeladditionreactionofanthronetoβnitrostyrenewascatalyzedbynovelfourkindsofC2axischiralBINOLaecatalysts.Theoptimumconditionsfthisreactionarethemolarrati

6、oofanthronetonitroolefinis0.05mmol:0.05mmolusing15mmol%ofaC2axischiralganicsmallmoleculecatalystatroomtemperaturewiththepresenceof2mmoloftolueneasthesolvent.Therearetwelveenantiomericallyrichedsubstituentnitroanthronewit

7、honechiralcenterswassynthesizedallcompoundswereacterizedby1HNMR13CNMRIRmeltingpoint.2.Theasymmetricreactionofindoletoβnitrostyrenewascatalyzedbynovelfivekindsofchiralpyrroleaeganicsmallmoleculecatalyst.Theoptimumconditio

8、nsfthisreactionarethemolarratioofindoletonitroolefinis0.05mmol:0.05mmolusing10mmol%ofapyrrolidineaebasedganicsmallmoleculecatalystatroomtemperaturewiththepresenceof2mLofdichlomethaneasasolvent.Therearetwelveenantiomerica