酒渣鼻患者面部微生物寄生狀況研究及細菌藥敏實驗分析.pdf

1、青島大學碩士學位論文酒渣鼻患者面部微生物寄生狀況研究及細菌藥敏實驗分析姓名：劉俊杰申請學位級別：碩士專業(yè)：皮膚病與性病學指導教師：臧運書20080607ClinicalSignificanceofthepredominantbacterialstrainsanddemodexonrosaceaAbstractobjective：Tounderstandtherelationshipbetweendemodexandbacteriainf

2、ectioninrosacea；investgatebacteriaflorainthelesionsofthepatientswitllrosaceaandantibioticresistanceofbacteriafrompatientswithrosaceaMethods：Theskinsamplesfromthelesionandtheneighboringregionsin60rosaceapatientswerecollec

3、tedforassay111eskinsamplesWasusedtodetectdemodexonthenasalpartandfrontalregionsebumandtissueonfaceWasscrapedandculturedtoexaminebacteria111ecomparativestudyWasalsomadebymatchingthe60skinsamplesfromnormalcontrols111edataw

4、ereanalysedbystatisticsResults：Rwasfoundthat48(80％)of60Cases、Ⅳimrosaceawereinfectedbydemodex，thepositiveratewashigherwhencomparedwiththenormalcontrolsTheisolationrateofbacteriainrosaceagroupWashigherthanthatnormalthemost

5、commonbacteriaisolatedwasGrampositivebacteria，includingstaphylococcusEpidermidisSsarophyticusandSAureusthemostcommonanaerobeisolatedWaspropionibacteriumGenerallytheywereinthestateofthesubclinicalinefetion111eclinicalinef

6、etionusuallyhappenedwhenthehumanbodyresistanceforbaeteriaWasdecreasedthehumanbodyresistanceforbaeteriamaydecreasedwhendemodexinfectionwasfoundinrosaceaInallofthebacterium，theresistantratetoxithromycinandMetronidazoleWas3

7、92％and996％TheratetoChloromycetinWasthelowest(289％)Conclusion：DemodexandbacteriainfectioninrosaceaareimportantfacorinducingrosaceaThebacterianotoftendetectedinthefacewerenotalsodiscoveredandapositivecorrelationwasnotobser

8、vedbetweenthedemodexandbacteriainfection(PO05)ThemostsensitiveantibioticsforthebacteriaofrosaceaiSChloromycetinPostgraduate：JunjieLiu(Dermatology)DirectedbyprofYunshuZangKeyWords：Rosacea，Demodex，Bacterialculture，Antimicr