后程γ-射線立體定向放射治療中晚期宮頸癌的臨床研究.pdf

1、內(nèi)蒙古醫(yī)學(xué)院碩士學(xué)位論文后程γ射線立體定向放射治療中晚期宮頸癌的臨床研究姓名：郁圣陶申請學(xué)位級別：碩士專業(yè)：影像醫(yī)學(xué)與核醫(yī)學(xué)指導(dǎo)教師：郁志龍20090501TheClinicalStudyofLateCourseY—rayStereotacticRadiotherapyforMiddleorAdvancedCervicalCancerAbstractObjectiveToevaluatethe3一month，one—yeareffect

2、iverate，one—yearsurvivalrateandradiationtoxicitiesoflatecourse1一raystereotacticradiotherapy(LCSRT)onmiddleoradvancedcervicalcancer，comparedwiththoseitemstreatedwithconformalradiotherapy(CRT)atthesametimeMethods60cases而tl

3、lmiddleoradvancedcervicalCanOBrrandomdividedintotwogroups30patientsweretreatedbyLCSRTwitll1824Gy／6—8f，3f／w，afterthewholepelvicradiotherapy衍tlltheprecribledclose50Gy／25fattheearlyfiveweeksWhiletheCRTgroupof30casesaccepted

4、intracavitaryirradiationwith42Gy／7f，6Gy／f，If／w，combined誦tIlexternalradiotherapyfor30Gy／15fResultsIntheshort—termeffect，theLCSRTandCRTgroupabout3一montheffectiverateareboth967％(29／30)(X2=03515，P=08388)；intheone—yeareffecti

5、verate，theyare90％(27／30)and933％(28／30)respectively(X2=06133，P=O8934)and90％(27／30)and967％(29／30)respectively(X2=02679，P=O6048)intheone—yearsurvivalrateThe3一month，olleyeareffectiverateandoneyearsurvivalratearenosignificant

6、differencebetweentwogroupsThe3一monthtoxicitiesindigestivesystem434％and70％(X2=66996，P=00351)andurinarysystem30％and333％(X2=41724，P=00411)arestatisticalsignificantbetweentwogroups，theLCSRTgroupissuperiortotheCRTgroupForoney

7、ear，twogroups’toxicitiesindigestivesystemare267％and50％(X2=52509，P=00219)，andthoseinurinarysystemarcboth67％(X2=00000，P=10000)ConclusionTheseresultssuggestthat，inimprovingeffectiverateandsurvivalrate，intracavitaryirradiati

8、oncombinedwithexternalradiotherapyandlatecourseY—raystereotacticradiotherapywerenosignificantdifferenceintreatingmiddleoradvancedcervicalcancerButthecomplicationscausedby7一raystereotacticradiotherapywererelativelylightTh

9、ismethordCanreplaceconformalradiotherapyintreatingcervicalcanceranditCanbeusedinthoseparentswhocannotaccepttraditionalintracavitaryirradiationcombined講tllexternalradiotherapyKeywords1一raystereotacticradiotherapycervicalc