CT灌注成像方法在評估腦轉移瘤放射治療療效中的應用.pdf

1、委糾犬孚碩士學位論文(2006屆)CT灌注成像方法在評估腦轉移瘤放射治療療效中的應用ApplicationofCTPerfusionlmagingjntheEvaluationoftheEffectsofBrainMetastaseswithRadiationTherapy研究生姓名——一苧盤墨指導教師姓名婆盤鹽【型塾絲!專業(yè)名稱受堡匡莖生楚墮堂研究方向盟絲量堡一論文提交日期!!!生!目ApplicationofCTPerfusionI

2、magingintheEvaluationoftheEffectsofBrainMetastaseswithRadiationTherapyAbstractObjectiveToinvestigatethevalueofCTpeffusionimagingintheevaluationoftheeffectsofbrainmetastaseswithradiationtherapyMethodsBothconventionalandpe

3、rfusionCTwereperformedin20patientswithbrainmctasta∞sbeforeandafterwholeradiotherapyrespectivelyThentheTDCcurveswereobstained，andcerebralbloodflow(CBDmaps、cerebralbloodvolume(CBV)mapsandtimetopeaktTn)mapsweregeneratedTheC

4、BF、CBVandTIPofthereagionofinteresttRODWeremeasuredontheperfusionmaps，andthentherelativeCBF(rCBF)、relativeCBV(rCBV)、relativeTrP(rTTP)andtherelativeMTT(rMTT)werecalculatedTheCTpeffusionparametersoftheparenchymatoustissueof

5、brainmctastasesandthenormalbrainfismebeforeandaftermdiothempywerecomparedTneeffectsofradiotherapyofthebrainmetastaseswithdifferentperfusionpammctersandwithdifferentpathologicsourceswerecomparedtooResultsTherCBF、rCBVofmos

6、tbrainmetastasesbeforeradiationtherapywereincreasedsignificantlythevalueswere527209、324107respectivelyTherMTrWaSincreasedandther珊wasdecreasedalitIle曲evalueswere154046and085025respectivelyAfewbrainmetastaseswhichweresmall

7、(D150ram)hasnosignificantshowingOntheperf[IlsionmapsThetumorsof2caseshadnosignificantchange，butthetumors’volumeofother18casesdecreasedtoagreaterOrlesserdegreeTheCBF、rCBF、rCBVoftheparenchymatoustissueoftumorsdecreasedsign