背向散射積分技術(shù)評(píng)價(jià)紫杉醇+順鉑聯(lián)合化療對(duì)肝腎毒性的臨床研究.pdf

1、Objective：To evaluate the clinical value of integrated backscatter(IBS) parameters in detecting the hepatic and renal toxicity by symphysic chemotheraphy(Paclitaxel and Cisplatin)． Methods：Forty-five patients have finish

2、ed 4 cycles of TP symphysichemotherapy(Paclitaxel and Cisplatin)(21 days per cycle)or more for malignancy treatment(A group)．Until the finally day of TP symphysic chemotherapy，the shortest course of treatment is four cyc

3、lese and the longest course of treatment is seven cyclese；the total minimal dos of PTX is 480mg／m2 and the total maximal dos of PTX is 840 mg／m2；the total minimal dos of DDP is 400mg／m2，the total maximal dos of DDP is 70

4、0mg／m2．And forty volunteers without liver and kidney diseases served as the control group(B group)were included in our study．The conventional ultrasonic parameters of liver and ren were respectively measured．And the conv

5、entional ultrasonic parameters were also obtainted．Obtained Parameters include：1、The conventional ultrasonic parameters：the right hepatic lengthes，portal vein inner diameters；the two renal lengthes and widthes，and thickn

6、esses of renal cortexs of the two groups．2、IBS parameters：The integrated backscatter (IBS) and examined IBS％ of liver and ren of the two groups were obtained．Results1、The conventional parameters comparison：the gender、a

7、ge and hepatic sizese and renal sizese had no significantly difference between groups A and B(P>0．05)．2、 IBS parameters comparision：the IBS parameters of livers in A group were significantly higher than those in B group(

8、P<0．0 1)．Aecording to CTC 3．0，IBS and IBS％in group A that include patients whose livers had not damaged and those patients whose livers had damaged were significantly higher than those in B group(P<0．05，P<0．0 1)．But in A

9、 group these parameters that were compared had no significantly difference (P>0.05)．the IBS parameters of rens in A group were significantly higher than those in B group(P<0．01)．According to CTC 3．0，IBS and IBS％in group

10、A that include patients whose rens had not damaged and those patients whose rens had damaged were significantly higher than those in B group(P<0．05，P<0．0 1)．But in A group these parameters that were compared had no signi

11、ficantly difference(P>0．05)．Conclusions：Integrated backscatter parameters may be valuable in the assessment of hepatic and renal toxicity by symphysic chemotheraphy(Paclitaxel and Cisplatin)，especially the assessment of