地塞米松對(duì)實(shí)驗(yàn)性過(guò)敏性鼻炎小鼠血清和鼻中隔黏膜TGF-β表達(dá)的影響.pdf

1、山西醫(yī)科大學(xué)碩士學(xué)位論文地塞米松對(duì)實(shí)驗(yàn)性過(guò)敏性鼻炎小鼠血清和鼻中隔黏膜TGFβ表達(dá)的影響姓名：成娜莎申請(qǐng)學(xué)位級(jí)別：碩士專業(yè)：耳鼻咽喉頭頸外科指導(dǎo)教師：張克軍20100420山兩醫(yī)科大學(xué)碩士學(xué)位論文AninVestigationontheefkctsofdexamethasoneonTGF—pleVelintheserumandnasalseptalmucosaofmousewithexperimentalallergierhinitis

2、AbstractObjec晰e：ToinVestigatetheeffectsofdex鋤e她sone(DEX)onTGF—pleVelsinthesenlIllandnaSalseptalmucosaofmouse麗thexperinlentala11e唱icrhinitis(EAR)Methods：Fo啊BALB／cmiceweremdomlyassignedt0four印ups，includingnomalcontrolgroup

3、(A)，modelcontrolgroup(B)andtwo仃eatmem伊oups(CarldD)EARmodelwassensitizedwithovalb啪in(OVA)Symptomscore，hematoxylineosinforeosinophilin丘ltration，andiInmunostaillingforTGFpinnasalmucosawereaIlalyzedaSwen弱enz)rmelinkedim瑚unos

4、orbemassay(ELISA)waStakentodetectTGF—pandIgEinsemspss115so腳arew舔usedt0analyzetheempiricaldammI沁sultswereshown越mean士SEUsingaone—wayANOVAforcomp撕sonofcontrolversustrea_tmentT11ethresholdforsigIlificance、懈PO05)111ereisnoTGF

5、—pexpressioninnasalseptalmucosaofAgroup，butitiseVidentinBgroupTheexpressionofTGFpinnasalseptalmuCosainbothtrIjatment莎oupsarelowerthaIlgroupB(PO01)Conclusion：ThisstlJdysuggeststhatDEXcaIlir山ibitthedi疵rentinductionofrmalal

6、le瑪yaccordingtothetimeofitsadminis拄ation。DEXwhenadminiSteredbeforegeneralsenSi_ti撕?，攕uppressesearlyandlateallergicreactioIlsDEXadmillimationbeforelocalchallengeinsensitiZedmicecallomysuppresslatealle唱icreactionsDEXmaypla

7、yall婦porrtantrolethrou曲atleasttwokindsofmech砌smsi11innuencingtheexpressionofTGFpinthecourseoftrea：tmentofalle畫(huà)crhinitisOnekindbyincreasingtllethesemmleVelofTGF—ptosupprcssalle畫(huà)creaction，a11dtheotherkindthrou曲theinllibiti