不均一性核糖核蛋白A2-B1、B1在肺癌中的表達(dá)及臨床意義.pdf

1、Y781564碩士學(xué)位論文(2005屆)不均一性核糖核蛋白A2／B1、B1在肺癌中的表達(dá)及臨床意義ExpressionofHnRNPA2／B1，HnRNPBlandtheirClinicalSignificanceinLungCancer研究生姓名塞9亟進(jìn)指導(dǎo)教師姓名塑坐盛(絲撞2專業(yè)名稱豎叢由登研究方向墮疸的盜逝墨漁疽論文提交日期!!!!生!旦墜坐業(yè)!!!堅(jiān)!墮!塑!：堅(jiān)!墜型型型!坐塑!!鯉!璺堅(jiān)墮墊!g!竺竺壘!!墮!Expres

2、sionofHnRNPA2／B1，HnRNPBlandtheirClinicalSignificanceinLungCancerAbstractObjectiveToinvestigatethecorrelationbetweenHnRNPA2／B1，HnRNPBloverexpressionandlungcancerdevelopmentandtoevaluatetheirvalueintheearlydetectionforhuma

3、nlungcancelMethodsHnRNPA2／B1mRNAandHnRNPBlmRNAwereseparatelystudiedinlungcauceroustissuesandparacanceroustissuesbyRTPCRWeanalyzedandcomparedthedifferenceandthechangingtendencybetweentheminallTNMstagesandhistologicaltypes

4、oftumorsResults①Thepositiverate(791％)ofHnRNPA2／B1incanceroustissueswassignificantlyhigherthanthatinparacanceroustissues(333％)(P001)AndHnRNPBlwas814％to40％f尸001)(墓)ThcrcwasatendencythatthelaterTNMstagewas，thelessexpression

5、ratesofHnRNPA2／B1andHnRNPBlwereTheyhadgreaterexpressioninthepreneoplasticlesionsandearlystageUllnors，anddecreasedinadvancedtumors(耍)HnRNPA2／B1andHnRNPBlwerefoundlessfrequentlyinadenocarcinomacomparedwithothershistologica

6、ltypesThereWasnosignificantassociationbetweenHnRNPBImRNAlevelandhistologicaltypesoftumors④wbanalyzedthelevelofbothHnRNPA2／B1mRNAandHnRNPBlmRNAisolatedfromcancerous(T)andnoncancerous(N)dssuesHnRNPA2／B1mRNAWasequallyexpres

7、sedinthecancerousandnoncanceroustissues(“N=09～15)However，HnRNPBlmRNAwaSespeciallyelevatedincanceroustissuescomparedwiththelevelinnoncanceroustissuesrr／N=15～734)ThelevelofHnRNPBlmRNAgraduallydecreased、ⅣiⅡlthestageadvancin