血漿鋅水平和2型糖尿病的關(guān)聯(lián)研究.pdf

1、Background:
　　Diabetes mellitus is a major health care problem. The relationship between type 2 diabetes and zinc has frequently been reported in various researches. This study has two major purposes:(1) To investigat

2、e plasma zinc level in healthy normal glucose tolerance (NTG) and type 2 diabetic (T2DM) (2) To demonstrate the relationship between zinc plasma level and T2DM.
　　Methods:
　　A case-control study was used which incl

3、ude two groups:718 NTG healthy individuals as control group and 658 T2DM individuals as case group. The plasma zinc level was determined by inductively coupled plasma mass spectrometry (ICP-MS). Personal information on d

4、emography was collected by using medical health questionnaire.
　　Results:
　　The T2DM group compared with the control group showed a significantly higher prevalence on age, body mass index, fasting glucose level, fa

5、mily history of diabetes and hypertension history, (P<0.001). The zinc plasma level for T2DM group median (1.05 mg/l), was significantly lower compared to control group (1.63 mg/l), (P<0.001). The frequency table showed

6、that along with increasing the zinc concentration the frequency numbers were significantly decreased on T2DM, while the control group was just the opposite (P<0.001). Crude OR value, for II, III, IV Zinc level were 0.319

7、 (95％CI, 0.227-0.447), 0.177 (95%CI, 0.126-0.249), 0.045 (95%CI, 0.031-0.068) respectively (P<0.001). After adjustment of age, sex, BMI ,family history of diabetes and fasting plasma glucose and history of hypertension,

8、and even in further stratification analysis for subgroup, the OR values still showed gradually decreasing trend along with the increasing zinc concentration, and the values were less than 1,with highly significant relati

9、on ( P<0.001).
　　Conclusion:
　　The results show that T2DM group plasma zinc level is significantly decreased, which means as the zinc concentration decreasing it is the more likely to develop type 2 diabetes, which