子宮內(nèi)膜異位癥和促排卵對(duì)IVF-ET周期的影響.pdf

1、華中科技大學(xué)博士學(xué)位論文子宮內(nèi)膜異位癥和促排卵對(duì)IVFET周期的影響姓名：穆罕默德申請(qǐng)學(xué)位級(jí)別：博士專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：朱桂金2002.4.1#中科技人學(xué)同濟(jì)醫(yī)學(xué)院嚏畢業(yè)論t!上乞inandinfertilityformthebigfontaddressofendometriosismeaningtheyrepresenlthechiefcomplaintofendometrioticpatientsAspaincanbeeluci

2、datedbyfheadhesionscausedbyendometriosiswithinthepelvis，thecaseisnotalwaysthesametoexplainlheassociatedinfertilitythatiswhenendometriosisinvolvestheovariesandcausesadhesionsandpelvicdistortionthereisnoquestionofitsrolein

3、causinginfertilityTheassociationbetweenminimaIendometriosisandinfertilityisIesswelldocumentedMedicaItherapyinthesecasesdoesn’talwaysimproveinfertilityInthelasttwodecadesanewhistoryfsmadeinreproductivemedicineandfheword“i

4、nfertility”hasIeftitsplacelothenewconcepl“fecundityproblems”so：lhankstofheassistedreproductivetechniques(ART)whichmadethatpossiblebyofferinghelptoalmostallpatientshavingproblemstoestablishpregnancyThus，ARTbecameaquickand

5、mosthopefullyhelpingmethodinmanagingfecundityproblemsthatassociatesendometriosisAsarelatively，newapproachinmanagingendometriosisassociatedinfertilityinsistingquestionshavebeenemergedregardingtheinteractionsbetweentheendo

6、metrioticIesionsandthehyperstimulatedovariesandwhethertheseinteradionsfexistedwouldeffectthefertilizationandpregnancyratesandtowhichextentThisstudyisanattemptfoexploretheseinteractionsandtheirretiectonlVF—ETprogramsproce

7、ededbyendometrioticpatientsinanattempltoclearupthisinterrelationwhichhopefullyInlurnwouldattracttheattentionofbothphysicianandpatientwhenmanagingthisdiseaseFollicularfluidasitisasharingenvironmentlhatisaffectedbothbyendo

8、metdosisandovarianhyperstimulationhavebeenregardedapossibleusefultooIforthepurposeofthisstudyToachievethegoaIofthisstudywefirsttriedtoexplorethemicroenvironmentaIalterationscausedbyendometriosisandovarianhyperstimulation

9、withinthefoIlicularfluidThenweinvestigatedtheeffectsofthesealterationsonthegrowthandproliferationofendometrialceilswhichtheyresembletheendometrioidimplantsAndtheninvestigatedthepossiblecauseeffectrelationshipbetweenendom

10、etriosisandassociatedinfertilitybystudyingtheeffectsofthisalteredmicroenvironmentonlhegrowthofpreembryosandreactionofacrosomesThentheoutcomesofIVFETprogramsofalIpatientssubjectedtothisstudyhavebeenanalyzedFinallyasIVF—ET

11、programssolvethepossibleimpairmentofalteredfoIlicularfluidmicroenvironmenttowardtheoocyte，sperm，andembryo，thisstudyalsotriestoanswertheemergedquestionofwhatelsecouldbethereasonofIVFETfailuresinfhesepatients，byinvestigati

12、ngthepotentialoftheirspareembryostodevelopin—vitrointoblastocyststageBecausethisstudyiscomposedoftwomainpartsclinicalandexperimentalfhecomponentshavebeenreorderedtohopefully，giveaclearpicturethatwouldmeeffhepurposesofthi