Fe-,3-O-,4-納米顆粒的制備及其急性毒性.pdf

1、Y785376國內(nèi)圖書分類號國際圖書分類號學(xué)位論文密級：Fe。0。納米顆粒的制備及其急性毒性董晶瑩2／oL9號導(dǎo)師姓名：劉寧教授申請學(xué)位級別：工學(xué)碩士專業(yè)名稱：食品科學(xué)論文提交日期：2005年4月答辯日期：2005年6月11日所在單位：東北農(nóng)業(yè)大學(xué)食品學(xué)院學(xué)位授予單位：東北農(nóng)業(yè)大學(xué)學(xué)位授予日期：2005年6月11日答辯委員會主席：平文祥教授2005年4月27日ThePreparationandAcuteToxicityofFe304na

2、noparticleAbstractNanosizedmaterialisalsocalledultramicroparticlematerial，composedofnanoparticlesItneitherbelongstomicrosystemnormacrosystem，butbetweenthemIthasmanyparticularcharacterizations，suchasvolumeeffect，surfaceef

3、fect，quantasizeeffect，macroscopicalquantatunneleffectandSOonbecauseofitsphysicalandchemicalperformancesdifferentfromnubblysolidManyresearcheshavefocusedonitsapplicationincrossedsubjectsuchasbio—medicalfieldCombiningFes04

4、nanoparticiesandexopolysacchridesfrombifidobacteriumenhancestheirusingefficiencybecausenanoparticlesarelittletoxicalornotandnoteasilydegradedbyenzymeandpossessgoodabsorptionAsasubquestionfordiscussionofnationalnaturalfun

5、d，thisarticlewastoprepareFe304nanoparticlesanddisscusstheirinfluencingfactorsinordertoestablishtheoreticalfoundationforanti—cancerandantitumourfoodandmedicine，ThisarticlefocusedonthepreparationofFe304nanoparticlesbycopre

6、cipitationandtheirmodificationbysodiumoleateAtthesametime，thestabilizationofnon—modifiedandmodifiednanoparieleWasalsostudiedTheresearchresultsobtainedwereasfollows：(1)Continuousnitrogenandceaselessagitatingandtitrationme

7、thodofalkaliwereallofimportanceforthewell—proportionedsizeThetechnicalconditionwas：temperatureWasbetween30and50centigrade，finalpHvaluewasbetween10and12，theratioofFe”andFe”wasO5，concentrationofferriteWaS01mol／L，stirringve

8、locityWas2000r／minThesizeofobtainedparticleswas15am(2)Dispersiveresultsindicatedthatultrasonichadlimitedseparateabilityevenmorethan2minutesbutacidhadbettereffbctatpHvalue3CombiningultrasonicandacidtreatmentWasfeasiblefor

9、betterdispersion(3)Sodiumoleate，asakindofanionsurfaceactivereagent，itsmodificationconditionwas：pHvalueWas5，thequantityaccountedfor20％oftotalwaterishnanoparticlepowderthetemperatureWas80centigrade(4)Themodifiednanoparticl

10、eshadbetterstabilitiesunderlowerconcentrationandlowercentrifugalrateandpHvaluehigherthan64Withthetremendouschangesinphysi—chemicalcharacterizationandpropertyandintensityofbioeffbctthebio—securityofnanoparticleshavebeenpa

11、idattentiontOManyfactorssuchassurfacearea，amount，chemicalcharacterization，surfacecoatedcondition，freshnessandvarietyandcategoryofexperimentalanimalallaffecttheirtoxicintensityThisarticlestudiedtheacutetoxicityofFe304nano