短暫性腦缺血發(fā)作-輕型卒中患者認(rèn)知功能障礙與尿酸的相關(guān)性.pdf

1、分類號：R74密級：公開UDC：610學(xué)校代碼：11065碩士專業(yè)學(xué)位論文短暫性腦缺血發(fā)作輕型卒中患者認(rèn)知功能障礙與尿酸的相關(guān)性董莘哲指導(dǎo)教師趙仁亮（教授）學(xué)位類別臨床醫(yī)學(xué)碩士專業(yè)領(lǐng)域神經(jīng)病學(xué)答辯日期2017年5月20日Associationbetweenserumuricacidlevelstransientischemicattackmildstrokepatients’cognitiveimpairmentAbstractObje

2、ctive:Thecognitiveimpairmentcausedbyischemicstrokeiscalledvularcognitivedysfunction.Transientischemicattackminstroke’sympromsaremild，butalsoaffecttheadvancedneurologicalfunctioneveninducevulardementia(VaD).Identifythecog

3、nitivefactsinearlystage，timelyeffectivetreatmentcanreducedelaythedeteriationofcognitiveimpairment.Thepurposeofthisstudyistoinvestigatethecrelationbetweencognitivedysfunctionuricacid(UA)inpatientswithtransientischemicatta

4、ck(TIA)minstroke.SubjectsMethods:133caseswithTIAminstrokewererecruitedintheaffiliatedhospitalofQingdaouniversityfromDecember2015toSeptember2016.Atotalof116eligibleparticipantswereenrolledinthisstudy.Demographic(agegender

5、educationlevel)histyofdisease(hypertensionconaryheartdiseasediabeteshyperlipidemiaatrialfibrillationcerebrovulardisease)lifestyle(smokingdrinkinghisty)clinicaldata(uricacidtriglyceridelowdensitylipoproteincholesterolhigh

6、densitylipoproteincholesterolserumcreatinine)ofpatientswerecollected.116patients(63patientswithTIA54patientswithminstroke)wereassessedbyMoCAafter3months.AccdingtotheMoCA’sce116patientswasdividedintocognitivedysfunctiongr

7、oup(49cases)nocognitiveimpairmentgroup(67cases).Comparethesetwogroups’demographicclinicaldatalifestylehistyofdiseasemedicationhisty.Toinvestigatethecrelationbetweenuricacidcognitivedysfunctionaftertransientischemicattack

8、minstroke.Results:Comparisonbetweencognitivedysfunctiongroupnocognitiveimpairmentgroup，therewerenosignificantdifferencesinagegendereducationallevel.ThelevelsofUAcerebrovularmbidityinthecognitivedysfunctiongroupwere(415.6

9、358.63)μmolL60.98%(2541)respectivelywhichweresignificantlyhigherthanthoseinthenocognitiveimpairmentgroup(308.7445.32)μmolL23.91%).Thedifferencewasstatisticallysignificant(P0.05)LogisticregressionanalysisshowedthatplasmaU