關(guān)于乳腺癌新輔助化療前后聲像圖變化的意義的問(wèn)題

1、關(guān)于乳腺癌新輔助化療前后聲像圖變化的意義的問(wèn)題關(guān)于乳腺癌新輔助化療前后聲像圖變化的意義的問(wèn)題文發(fā)布者：來(lái)源：尋醫(yī)問(wèn)藥網(wǎng)關(guān)于乳腺癌新輔助化療前后聲像圖變化的意義的原因關(guān)于乳腺癌新輔助化療前后聲像圖變化的意義的相關(guān)知識(shí)。乳腺癌新輔助化療前后聲像圖變化的意義中華超聲影像學(xué)雜志2000年第8期第16卷臨床研究作者：王艷濱陳敏華張暉嚴(yán)昆廖盛日王天峰林本耀單位：王艷濱（100036北京腫瘤醫(yī)院超聲科；現(xiàn)在華北煤炭醫(yī)學(xué)院附屬醫(yī)院超聲科）；陳敏華張暉嚴(yán)

2、昆廖盛日王天峰林本耀（100036北京腫瘤醫(yī)院超聲科）關(guān)鍵詞：超聲檢查乳腺腫瘤藥物療法【摘要】目的對(duì)乳腺癌術(shù)前新輔助化療后超聲各指標(biāo)的變化進(jìn)行觀察分析，旨在探討超聲對(duì)其療效評(píng)價(jià)的意義。方法42例進(jìn)行新輔助化療的乳腺癌患者，于化療前、化療后、手術(shù)前分別對(duì)乳腺癌原發(fā)灶及腋窩淋巴結(jié)進(jìn)行觀察及分析。結(jié)果42例患者新輔助化療后超聲檢查顯示，32例乳腺癌原發(fā)灶體積顯著縮??；形態(tài)不規(guī)則者由化療前3例增至化療后31例；周邊有強(qiáng)回聲帶者由化療前16例降至

3、化療后4例；邊界清晰者由15例增至化療后37例；腫物內(nèi)回聲偏多者由化療前2例增至化療后27例；化療前未見(jiàn)囊性變，化療后3例發(fā)生囊性變；后方回聲有改變者由34例降至化療后9例；有29例原發(fā)灶內(nèi)血流豐富程度降低或消失；Vmax、RI值降低(P＜0.05，P＜0.025)。共發(fā)現(xiàn)29枚腫大淋巴結(jié)，化療后21枚縮小或消失；有7例淋巴結(jié)內(nèi)可檢測(cè)出血流信號(hào)，化療后5例血流豐富程度降低。結(jié)論乳腺癌新輔助化療后，原發(fā)灶和腋窩淋巴結(jié)的二維圖像及彩色多普勒

4、的多項(xiàng)指標(biāo)發(fā)生顯著性變化，超聲檢查有助于對(duì)乳腺癌化療療效的評(píng)價(jià)。ThevalueofultrasonographyappliedinassessmentofpreadjuvanttherapyfbreastcancerWANGYanbin，CHENMinhua，ZHANGHui（DepartmentofUltrasonographySchoolofOncologyBeijingMedicalUniversityBeijing100036

5、China）【Abstract】ObjectiveToinvestigatethevalueofultrasonographicalassessmentinbreastcancerbyanalyzingthechangeinsonographicaldataof42patientsfollowingprimarymedicaltherapy.MethodsAltogethertwosetsofultrasonographicdata(i

6、ncludingthatofprimarytumaxillarylymphnodes)clinicalassessmentweretakenbefeaftermedicaltherapyindependently.Allofthesonographicalexaminationswereperfmedwiththe6.0～9.0MHzlinerarrayprobe.ResultsAftertreatmentultrasonographi

7、cfeaturesofprimarytumwerefoundchangeinlargelyproptionwhichwerereducinginvolumemphologyirregularityexistenceofsurroundinghalodistinctboundaryincreasingofinternalechoesrearechodecreasingofcolDopplersignalsreducingofvalueof

8、VmaxRI.ChangesofaxillarymetastasislymphnodeswerefoundsuchasreducinginvolumedecreasingofcolDopplersignals.ConclusionsThesechangesofUSfuturesabovedemonstratedwerehelptoassessmenttheeffectivenessoftreatmentfollowingprimarym

9、edicaltherapyinpatientsofbreastcancer.2.161.111.730.736.913.0215.988.05治療后1.980.931.580.781.230.593.771.655.812.16注：t檢驗(yàn)與治療前比較P＜0.05，P＜0.001表442例乳腺癌化療前后聲像圖變化（例）檢查時(shí)間形態(tài)邊界周邊聲帶內(nèi)部回聲后方回聲欠規(guī)整不規(guī)整清晰模糊有無(wú)弱均勻偏多囊性變?cè)鰪?qiáng)衰減無(wú)異常治療前39315271626

10、402015198治療后1131375438122734533χ238.7424.439.4536.5729.78P值0.0010.0010.0020.0010.001表242例乳腺癌治療后腫瘤大小變化（例）檢測(cè)方法例數(shù)不變縮小增大面積測(cè)量429294體積測(cè)量426324表3治療后腫瘤縮小程度比較（例）測(cè)量方法縮小例數(shù)腫瘤縮小比例＜30%31%～50%51%～70%71%～90%＞90%面積測(cè)量2976970體積測(cè)量322511104表