不同時程運動對抑郁癥模型大鼠行為學、血清皮質(zhì)醇及海馬單胺氧化類遞質(zhì)含量的影響.pdf

1、溫州醫(yī)學院碩士學位論文不同時程運動對抑郁癥模型大鼠行為學、血清皮質(zhì)醇及海馬單胺氧化類遞質(zhì)含量的影響姓名：何松彬申請學位級別：碩士專業(yè)：神經(jīng)病學指導(dǎo)教師：王小同唐聞捷20080501溫州醫(yī)學院碩士學位論文EffectsofExerciseatDifferentCoursesontheBehaviors，theSerumCortisolandMonoamineeurotransmit!inHippocam[‘DelModeiUeurotra

2、nsmlttersippocampusinDepresslonIVl011ellinducedbyChronicMildStressinRats[Abstract]objectiveToinvestigatetheeffectsofexerciseatdifferentcoursesontheserumcortisolandthemonoamineneurotransmittersinhippocampusinachronicmilds

3、tressmodelofdepressioninratsMethodsDesignated54SDmaleratsrandomlyweredividedintothreegroups：Firstgroupsincludedcontrolgroup，thestressgroupandtheexercisewithstressgroupSecondgroupsincludedcontrolgroup，thestressgroupandthe

4、exerciseafterstressgroupThirdgroupsincludedincontrolgroup，thestressgroupandtheexercisebeforestressgroupAllratswereexposedtoanunpredictablesequenceofmildstressorsfor21daysexceptthecontrolgroupsBodyweight，open—fieldtestand

5、fluidconsumptionwereinvestigatedduringthewholeprocedureAftertheexperiment，theradiationimmuni妙wasusedtomeasuretheserumcortisol，theconcentrationofmonoamineneurotransmittersinhippocampusofratbrainweredeterminedbyHPLCECDResu

6、lts1RatsexposedtoCUMSshowedreducedconsumptionofsucrosesolutionsandpreferenceforsucrosesolutions，decreasedsquarescrossedandrearingandincreasedbowelmovementinopen—fieldtest，whichwasmitigatedbytheexercisewithstressgroupandn

7、otbyafterstressgroupandnotbytheexercisebeforestressgroup2RatsexposedtoCUMSshowedasignificantincreaseofserumcortisol，whichwasmitigatedbytheexercisewithstressgroupandtheexercisebeforestressgroup3Comparedwithnormalcontrolan

8、dthestressgroup，theexercisewithstressgroupshowedsignificantlylowerontheserumcortisolandtheserotonininhippocampus(p005)4Comparedwithnormalcontrolandthestressgroup，theexerciseafterstressgroupshowedsignificantlyhigheronthes