EGFR、p-EGFR在食管鱗癌組織中的表達及臨床意義研究.pdf

1、EGFREGFR、pEGFREGFR在食管在食管鱗癌組織組織中的表達及臨床意中的表達及臨床意義研究義研究Expressionclinicalsignificanceofepidermalgrowthfactrecept(EGFR)pEGFRinesophagealsquamouscellcarcinoma論文類別：專業(yè)學(xué)位型論文類別：專業(yè)學(xué)位型作者姓名劉啟飛劉啟飛指導(dǎo)指導(dǎo)教師姓名教師姓名張闖張闖申請學(xué)位級別申請學(xué)位級別碩士學(xué)位授予單位學(xué)

2、位授予單位蚌埠醫(yī)學(xué)院蚌埠醫(yī)學(xué)院學(xué)科專業(yè)腫瘤學(xué)腫瘤學(xué)研究方向腫瘤內(nèi)科腫瘤內(nèi)科論文答辯時間論文答辯時間年月學(xué)位授予日期學(xué)位授予日期年月答辯委員會主席：答辯委員會主席：論文評閱人：人：年月分類號密級學(xué)校代碼10367UDC編號學(xué)號201174311922Expressionclinicalsignificanceofepidermalgrowthfactrecept(EGFR)pEGFRinesophagealsquamouscellcarc

3、inomaObjective：ToexpletherelationshipbetweentheEGFRpEGFRexpressioninesophagealsquamouscellcarcinomaitsclinicalpathologicalfeaturesprognosis.Methods：ByimmunohistochemicalmethodstodetecttheexpressionoftheEGFRpEGFRexpressio

4、ninesophagealsquamouscellcarcinomaadjacentnmaltissueanalysisofEGFRpEGFRexpressionclinicalpathologicalfeaturesprognosis.Results：1.ThepositiveexpressionrateofEGFRProteinexpressioninesophagealcancergastricnoncanceroustissue

5、swere69.57%(4869)8.70%(669).ThepositiveexpressionrateofpEGFRProteinexpressioninesophagealcancergastricnoncanceroustissueswere78.26%(5469)、44.93%(3169).2.NosignificantcrelationbetweenEGFRexpressionofthepatientsagesexcance

6、rhistologicaltypeTNMstagedepthoflocalinvasionbutapositivecrelationwithtumsizetumlocationlymphnodemetastasis.ApositivecrelationwithTNMstagebutNosignificantcrelationwithotherpathologicalfeatures.3.Nosignificantcrelationbet