PGMA-DVB聚合物微球的制備、改性及其在高效液相色譜中的應(yīng)用.pdf

1、 分類號(hào)： 分類號(hào)： N3 密級(jí)： 密級(jí)：不保密 不保密 UDC： 31 學(xué)校代碼： 學(xué)校代碼： 11065 碩士學(xué)位論文 PGMA-DVB 聚合物微球 聚合物微球的制備、改性 的制備、改性及其在高 及其在高 效液相色譜中的應(yīng)用 效液相色譜中的應(yīng)用 張宏博 張宏博 指 導(dǎo) 教 師

2、 楊淑靜副教授 學(xué) 科專業(yè)名稱 材 料 學(xué)論文答辯日期 2017 年 6 月 2 日 Abstract Polymer microspheres as one of the most common polymer morphology were widely used in chromatographic separation, drug delivery and other fields. At pre

3、sent, the preparation methods of polymer microspheres are also complex and diverse. Among them, seed polymer polymerization is easy to control, and the obtained polymer microspheres have uniform particle size and diverse

4、 morphology. It has been one of the most popular methods for preparing polymer microspheres. Although the method has been extensively studied in the past few decades, it is still one of the hotspots in the preparation of

5、 polymer microspheres due to the variety of factors affecting seed emulsion polymerization. In this study, the different types of swelling agent were introduced into seed emulsion polymerization. The effect on the morpho

6、logy of the polymer microspheres was studied. And the size of obtained micropsheres was uniform. The microspheres were successfully applied to chromatographic separation. This study includes the following two aspects: 1.

7、 Porous poly (glycidylmethacrylate-divinyl) (PGMA-co-DVB) microspheres with an average particle size of 4.6 μm were successfully prepared by seed emulsion polymerization, followed by modification with diazo resin (DR). T

8、hree porogens (toluene, cyclohexanol and dodecanol) were used in the preparation process to obtain porous microspheres with different morphologies. The polymer microspheres prepared from toluene as porogen have a large s

9、pecific surface area and are well pore structure and were used for further modification. The hydroxyl groups of the polymer microspheres are hydrolyzed to the hydroxyl group and then reacted with DR. After treatment with

10、 UV light, the hydrogen bonds between the hydroxyl groups and the DR were converted into covalent bonds by the unique photochemical reaction of DR. And the porous PGMA-DVB-DR microspheres were used as the stationary phas

11、e of high performance liquid chromatography (HPLC). DR-modified PGMA-DVB stationary phase can be used for mixed mode separation mechanisms, including reversed phase (RP) and hydrophilic interactions. The baseline separat

12、ion of benzene homologues was achieved by using porous PGMA-DVB-DR microspheres as the stationary phase. In addition, the by-product acetic acid can be rapidly separated from N-vinyl-1,2,4-triazole product. In addition,