涼血解毒法對實驗性大鼠肝纖維化PDGF及ET干預作用的研究.pdf

1、南京中醫(yī)藥大學碩士學位論文涼血解毒法對實驗性大鼠肝纖維化PDGF及ET干預作用的研究姓名：代海峰申請學位級別：碩士專業(yè)：中醫(yī)內科學（肝膽?。┲笇Ы處煟貉Σ╄?0080501ABSTRACTColdhearteddegassingtoexperimentalratsliverfibrosisPDGFand11rn●^‘E1interventiontunctionresearchAbstractThebodyofhepaticfibrosi

2、sisachromcliverinjuryandrepairresponses，butalsotoallkindsofchromcliverdiseasecirrhosisdevelopmentoftheinevitablestageCurrentlyrecognizedprimarilyinthepathogenesisofavarietyofcytokinesintheliver(cytokine，CK)participationf

3、romextracellularmatrix(Extracelluarmatrix，ECM)synthesisanddegradationofbalance，thatis，ofmorethandegradation，resultinginexcessivedepositionbytheECMHasbeenconfirmedthathepaticstellatecells(hepaticstellatecell，HSC)isthemajo

4、rECMproducelivercells，liverfibrosisHSCactivationisthecentrallinkVariousfactorSleadtoliverdamageliverinjury，andthencauselivercellnecrosisandinflammatorystimulation，avarietyofrelatedcellactivationCKHSC，agreatnumberofECMRec

5、entstudiesshowthattheECMcytokines，particularlycollagenproteinmetabolism，hasanimportantrole，andinmanycytokines，PDGFontheroleofliverfibrosisparticularconcernHasnowbeenconfirmedthattheliverfiberoftheoccurrenceanddevelopment

6、，andPDGFreceptorexpressionwassignificantlyhigherthanthatofnormaltissueitsactivity、析tllthedegreeofliverfibrosisandaddincreasedespeciallyintheexpressionofHSCanddegreeofliverfibrosisWassignificantlycorrelatedThismsearchtake

7、theChinesemedicinetheoryastheinstruction，throughtheclinicalreviewandtheexperimentalstudydiscussestheliverfibrosisthecauseofdiseasepathogenesis，thepathologytoevolve，totreattheFrancesidemedicineandthecurativeeffectmechanis

8、mThoughtthatthehepatitisliverfibrosisthecauseofdiseaseismainlypoisonousfortheexternaldiseasefactorshotanddampepidemicdisease，internalinjurydietorsentimentwillbeingoutofbalance；Thebasicpathogenesisfortheliverspleenkidneyd

9、amage，thevitalitytiesmutually；Thepathologyfactorhas，theheat，thepoison，thestasiswetandSOon；Andthestasishotwrestlesforitspathogenesiskeythetreatmentisdividedtheinitialperiodcoldhearteddisintoxicating，theclarificationishota

10、nddamp；Laterperiodadjuststhelivertotransportthespleenstraightensupremovingextravastedblood；ThetreatmentusesthemedicinehepatitisCpelletaftertheclinicalmanyyearapplicationobservation，thecurativeeffectisratheraccurateThisre