樹脂催化劑用于Vc生產中酯化工藝的研究.pdf

1、天津大學碩士學位論文樹脂催化劑用于Vc生產中酯化工藝的研究姓名：王清格申請學位級別：碩士專業(yè)：制藥工程指導教師：秦永寧高春平20021201AbstractInthispaperanewprocess，esterifying2keto—Lgulonieacidwithmethanolbystrongacidiccationexchangeresincatalyst，wasdevelopedinthesynthesisofvitaminC

2、TheoptimumtypeofcationexchangeresinwasselectedfromconventionalcommercialacidexchangeresinTheresultsshowedthatD72hasahigherlevelofcatalysticactivityinthisreactionWediscussedthemethodofdehydrationofexchangerandeffectofcata

3、lystieactivityoncontentofwaterofresin，aswellWehavestudiedtheimportantfactorswhichaffecttheesterificationyieldandtheoptimumesterificationprocessconditionsbyusingresincatalystwasdeterminedItisasfollows：operatingtemperature

4、6驢一62℃catalystbedheighttodiameterratio10thespacevelocity12—電8h～MoreoverafteradoptingthenewmethodologyofmanufacturingVc—Na(theintermediateofvitaminC)，ItwasobtainedthatthequalityandyieldofVcNahaveobviouslyimprovedAccording

5、totheresultsofsmall—scaletest，wehavedesignedpilottestreactorandsetupaproductionlinewhichcancharge2keto—Lgulonicacid60tonperyearAsaresult，wehavegainedasatisfiedesterificationtechnologyinwhichthecriticalstepsrequiredinthep

6、reviousmethodssuchas：neutralization，filtration，washingetcaretherebyavoidedThepracticalperformanceofthenewprocessissimpleandconveniencebesides，theprocessconditionsisgentleThereforeenergyandpowerconsumptioncanbedecreasedIn

7、halfyearofoperationtheresincatalystperformssatisfactorilyandthetechnicaleconomicalindexofproductkeepsstabilizingAsthequalityandyieldofmethyl2keto—Lgulonatewasimproved，thequalityandyieldofVcNawasgreatlyimproved。thecontent

8、ofdriedVcNareachedabove915％，itincreasedbyalmost2％thanthepreviousartprocess，andtheyieldincreasedto94％，itincreasedbyabout4％thanthepreviousprocessrawmaterialcostwasdecreasedO2798yuanperkgRMBSothisnewtechnologycanbeappliedin